What is a Grignard Reaction?

A Grignard reaction is actually a two-step chemical reaction that consists of:

  1. Formation of the Grignard reagent by reaction of Mg with an organohalide in a donor solvent.
  2. Reaction of the Grignard reagent with a substrate.

The Grignard reaction was discovered in 1899 by Philippe Barbier who assigned his graduate student, Victor Grignard, to investigate the reaction between organic compounds and metals. Grignard went on to spend a majority of his career studying this reaction between metals and organic compounds and broadening the scope of this organometallic chemistry.

Reaction Mechanism of the Grignard Reaction

Within reaction, the Grignard reagent acts as a nucleophile, which is a compound that gives an electron pair to an electrophile to form a chemical bond. The reagent in this reaction attacks the electrophilic carbon atom that can be found within the polar bond of a carbonyl group.

In addition to forming a carbon-carbon bond, Grignard reactions can also be used to form carbon-tin, carbon-phosphorus, carbon-boron, and carbon-silicon bonds.

Grignard reagents react with a variety of different compounds. The most common application is the alkylation of carbonyl compounds.

Grignard Reactions at CABB’s Jayhawk site

CABB is a global player in the specialty chemical industry. We use a range of different chemistries and technologies to develop and manufacture our fine chemicals, including Grignard reactions.

We are experienced in performing Grignard reactions for fine chemical synthesis, and we can provide the solution to any manufacturing issue you may have. If you would like any more information about our solutions, please contact us.