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May 19, 2020by Jayhawk0

Azo compounds are a diverse set of both natural and synthetic molecules containing at least one double-bonded nitrogen group (the “azo” group). Though there is an extremely wide range of azo compounds, the most common are pigments and dyes.

Bismarck Brown was the first commercial azo dye, which was produced from 1863. This sparked significant growth in the use of azo compounds during the 1880s, yielding a rich variety of additional azo dyes that were primarily used in the textile industry. Current applications for azo compounds include textiles, paints, printing ink, plastics, agrochemicals, pharmaceuticals, and more.

Fine Chemical Azo Compounds

Pigment and dye production generally do not require fine chemistry. However, for pharmaceutical, biomedical and agrochemical applications, fine chemical custom manufacturers play a critical role in the supply chain, addressing strict assay and impurity profiles.

Azo Compounds for Healthcare

Certain azo compounds are known to have antibiotic, antiviral, antifungal, antineoplastic, and cytotoxic properties. Fine chemical azo compounds can be a regulated starting material or an active pharmaceutical ingredient (API) for medications. Azo compounds can also be used to improve the delivery of a drug or for cellular staining to help the study of cells. Current research into naturally-occurring azo compounds is continually identifying potential new drugs to treat a wide variety of diseases.

Azo Compounds for Agrochemicals

Because of the way azo compounds react to light, there are many unique opportunities for their use in agrochemicals. For example, azobisisobutyronitrile (AIBN), an alkyl rather than an aromatic azo compound, is commercially important as a radical initiator in a wide variety of processes. Azo compounds have also been used to study how insecticides work by using azo compounds to turn the insecticide on and off with light for easier handling and more controlled experiments.

How are Fine Chemical Azo Compounds Produced?

There are several different methods of producing fine chemical azo compounds. One is through the use of azo coupling with a diazonium salt, formed by the oxidation of an aniline with nitric acid, and another aniline type molecule. Another route involves the oxidation of substituted hydrazines and the condensation of anilines with aryl nitro compounds, followed by oxidation of the azoxy intermediate. Finding the best pathway depends on a multitude of factors – a fine chemical manufacturing partner can help identify and refine the best way to obtain commercial quantities.

Azo Chemistry at CABB

CABB Group is a leading fine chemical custom manufacturer of starting materials, advanced intermediates, and active ingredients. CABB’s Custom Manufacturing business supports customers from 3 locations: Pratteln, Switzerland; Kokkola, Finland; and Jayhawk, USA, to offer creative solutions involving Azo chemistry.

If you would like more information about our products and services, simply contact a member of the CABB team today.

 

References:

https://www.ncbi.nlm.nih.gov/pubmed/29792144

https://aip.scitation.org/doi/pdf/10.1063/1.4945973

https://www.nature.com/articles/srep13962

 


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March 6, 2020by Jayhawk1

Coronavirus, more accurately referred to as COVID-19, is beginning to impact global supply chains in a tangible way. Although it is impossible to forecast the effect of numerous epidemics worldwide on the fine chemical supply chain specifically, reports suggest that as much as 94% of the Fortune 1000 are already experiencing coronavirus-related supply disruptions.

Fortune cites the devastating 2011 tsunami as a case study of how unforeseeable disasters can severely disturb supply chains with far-reaching ramifications. Damage to Mitsubishi Gas Chemical factories in the area affected by the tsunami led to a shortage of bismaleimide triazine (BT) resin; a critical material for electronic substrates. Over 90% of the world’s BT was engineered in northeastern Japan at the time. The result was a significant delay in electronic chip production and assembly of consumer digital devices.

Understanding the Fine Chemicals Supply Chain

Much like the global electronics industry, the fine chemicals market is built on a closely intertwined supply chain that could easily be disturbed by the currently intensifying climate.

Specialty and fine chemicals occupy a small but lucrative niche of the global chemical industry; a closely interlinked market that relies on the reliability of supply. Complex and pure chemical substances (fine chemicals) must be sourced, screened, and delivered in a timely fashion to facilitate the synthesis of complex compounds (specialty chemicals) that are selected for their performance rather than their compositional values. These intermediates underlie a potentially limitless range of market-oriented and functional products, from pharmaceuticals to petrochemicals.

Read More: Managing Your Pyromellitc Dianhydride Supply Chain in a Volatile Market

In recent years, the fine chemicals market has – like many others – been characterized by an East vs. West dichotomy. Asian chemical companies have been growing at rapid rates with low investment costs and typically reduced costs associated with regulatory compliance. The growth of China’s chemical market has proven particularly disruptive to the US as major players continue to acquire valuable secondary assets and invest in new intellectual properties. Chinese API manufacturers and pharmaceutical companies now service an extremely large proportion of the global market.

How Will Coronavirus Effect Fine Chemicals Supply?

Fears of coronavirus-related pharmaceutical ingredient shortages are subsequently well-placed. Large areas of China have ground to a halt due to quarantine protocols, which have caused worker shortages, market shutdowns, raw material shortages, and so on. The logistics of how to manage the bottlenecks of provincial border checkpoints has also become a factor affecting the global supply of fine chemicals and pharmaceuticals.

Even once ingredients are manufactured and successfully delivered out of the country, strict quarantine protocols at destination ports can result in a further delay of at least 14-days. Cancellations of product shipments are increasingly common as the virus propagates worldwide. From a pharmaceutical perspective, this is potentially hazardous as the reduced supply of APIs and pharma excipients to manufacturers that rely on raw materials from the large Chinese market could lead to a shortage of key medicines. Industry officials say that this is far from the case thus far but add that sustained supply chain disruptions could impact the availability of medicines down the line.

From the point of view of petrochemicals, industry analysts actually predict a decrease in demand due to closures or decreased productivity of factories using petrochemical feedstocks downstream, such as plastics processing. Consequently, industrial fine chemicals are likely to be sandwiched by COVID-19 related logistical issues including reduced supply and demand.

Current Fine Chemicals Supply Situation at CABB

CABB Group is a leading fine chemical custom manufacturer of starting materials, advanced intermediates and active ingredients.  CABB’s Custom Manufacturing business supports customers from 3 locations: Pratteln, Switzerland; Kokkola, Finland; and Jayhawk, USA to offer creative sourcing options while addressing supply chain security. We’ve minimized our raw material risk exposure and are working diligently to ensure continuous manufacturing operations and deliveries to global customers without disruption.

If you would like more information about our fine chemicals supply chain, simply contact a member of the CABB team today.

 

 

https://fortune.com/2020/02/21/fortune-1000-coronavirus-china-supply-chain-impact/

https://www.eetimes.com/update-analysts-fear-shortage-of-key-resin/#

https://www.scmp.com/economy/china-economy/article/3051534/coronavirus-chinas-manufacturing-supply-chain-pummelled-all


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August 15, 2019by Jayhawk0

Formulating Tips for Epoxy-Anhydride Cure Systems 8: Understanding BTDA Blends

Curing a basic DGEBA epoxy resin with a monoanhydride and dianhydride blend improves the thermal stability of your epoxy-based parts when operating in aggressive service environments. You are also able to adjust the blend to meet specific processing conditions while achieving a favorable cost position.
Accomplishing this requires careful consideration of specific parameters, including:

  • Selection of the anhydrides
  • Dianhydride/monoanhydride ratio
  • Accelerator selection and dosing level
  • Cure schedule

The Advantages of BTDA Blends

BTDA/NMA blends are an intriguing example of a dianhydride and monoanhydride combination that can deliver high-quality results. They also address the incorporation of a solid dianhydride into a liquid epoxy resin without resorting to solvents or diluents. If you are willing to take the time to formulate correctly, you can leverage blended epoxy-anhydride cure systems to gain a competitive advantage. In the video below, our experts discuss BTDA/NMA blends in greater detail.

Are you looking for more technical data on BTDA/NMA formulations? Do you have any other questions or comments on curing epoxy resins with anhydrides? Please reach out to us, we are happy to help.

Epoxy-Anydride Formulating Tips from the Experts

Jayhawk Fine Chemicals, Crosslink Technologies, Evonik and Dixie Chemicals performed a study on a variety of BTDA and NMA blends, with an emphasis on accelerator selection. A detailed presentation can be found here.

If you missed our last video, Formulating Tips for Epoxy-Anhydride Cure Systems 7: Pushing the Envelope, be sure to give it a watch. You can subscribe to our YouTube channel using the link below to get notifications with each new release.


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August 8, 2019by Jayhawk0

Modern technology is increasing the demand for high-performance components and creating opportunities for epoxy-anhydride systems to offer solutions in a variety of new applications. Filament-wound components, prepregs, bulk and sheet-molding compounds, and optically clear encapsulants are just some of the areas where epoxy-anhydride cure systems offer new and exciting options in demanding service environments.

Novel applications for epoxy-anhydride cure systems means new property requirements. For example, traditional epoxy-anhydride chemistry focuses on maximizing Tg and heat resistance; modern applications require a more careful balance of heat resistance and toughness. Similarly, traditional applications are tolerant of some coloration whereas new applications may require a water-white product. On the processing side, epoxy-anhydride cure systems need to maximize throughput without requiring new and expensive assets. This means finding ways to reduce curing temperatures and curing times. With the correct formulation, you can create a high-value epoxy-resin cure system that meets these challenges and provides a competitive edge.

In this video, our thought leaders provide further insight into the challenging new requirements epoxy-anhydride cure systems must meet. As the series continues, we will tackle different aspects of formulating mono/dianhydride blends with accelerators to help achieve the results you need.

Epoxy-Anhydride  Formulating Tips from the Experts

Jayhawk Fine Chemicals, Crosslink Technologies, Evonik, and Dixie Chemicals performed a study on a variety of specialty anhydride cure systems, with an emphasis on accelerator selection. The results of this study provide a foundation for improving epoxy-anhydride formulations and for creating new growth opportunities for formulators.

Thought leaders from these companies sat together to discuss the results as part of an informative video series. If you missed our last video, Formulating Tips for Epoxy-Anhydride Cure Systems 6: Processing Considerations, be sure to check it out. If you have any questions or comments, please contact a member of the team.

Be sure to subscribe to our YouTube channel using the link below to get notifications with each new release. If you have any questions or comments, please contact us directly.


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August 5, 2019by Jayhawk0

Epoxy-anhydride cure systems impart outstanding physical, mechanical, and electrical properties for a variety of critical applications. Fabricated parts are resistant to high-peak and continuous-use temperatures, retaining their properties in extreme operating conditions. With some basic processing and formulation considerations, you can utilize DGEBA class resins and create a high-performance epoxy at a competitive price point.

In the video below, our expert panel discuss processing considerations for epoxy-anhydride resin systems. We explore ways to overcome some of the perceived challenges in epoxy processing such as how to incorporate solid dianhydrides into a liquid resin. We also cover the use of monoanhydrides as reactive diluents and co-curatives along with other key topics. With proper formulation, blended curatives deliver the physical properties you seek in an elegant, easy-to-use, and cost-effective manner.

As the series continues, the panel will address specific process and formulation considerations to fully leverage epoxy-anhydride cure systems. Topics will include how to determine the correct levels of dianhydride and monoanhydride loading; and how to choose the correct accelerator for epoxy-anhydride cure system systems; and other formulation concerns to help give you a competitive edge.

A Comparative Analysis of Epoxy-Anhydride Cure Systems

Specialty anhydride and formulating experts from Jayhawk Fine Chemicals, Crosslink Technologies, Evonik, and Dixie Chemicals performed a study on a variety of specialty anhydride cure systems, with an emphasis on accelerator selection. The results provide valuable data and guidelines to help with your formulations and form the basis of our video series.

Please subscribe to our YouTube channel using the link below to receive notifications with each new release. If you missed it, make sure you check out our previous post Formulating Tips for Epoxy-Anhydride Cure Systems 5: Modern ApplicationsBe sure to subscribe to our YouTube channel using the link below to get notifications with each new release. If you have any questions or comments, please contact us directly.


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July 11, 2019by Jayhawk0

The market for high-temperature, high-endurance epoxy polymers continues to grow. This growth is largely driven by demand for consumer and automotive electronics to be more durable, lighter, increasingly compact, and able to function in various environments. As expectations increase, specifications normally found in niche products are becoming widespread in commercial versions. Epoxy-anhydride cure systems have a long tradition of meeting stringent specifications and continue to provide the best, most efficient path for epoxy formulators.

In the video below, our expert panel discusses the exciting growth in demand for epoxy-anhydride cure systems. In the next video, they will discuss how brand-new applications for anhydride cured epoxy resin provide even more opportunities for growth.

Investigation on Epoxy-Anhydride Cure Systems from specialty anhydride and formulating experts

To help you take advantage of the growing demand for epoxy-anhydride systems, Jayhawk Fine Chemicals, Crosslink Technologies, Evonik, and Dixie Chemicals completed an investigation into a variety of anhydride curatives, with a focus on accelerator selection. These results offer valuable data and guidelines for new users or experienced formulators looking to improve on epoxy resin performance.

Experts from these companies discuss the key benefits and applications of epoxy-anhydride cure systems. Previous videos review historic applications and the value proposition of epoxy-anhydride cure systems, as well as the need to dispel misconceptions. The next video will discuss how future technologies are providing even more opportunities to expand the market. After that, our panel will begin to discuss processing considerations and specific formulations to achieve the results you need.

Be sure to subscribe to our YouTube channel using the link below to get notifications with each new release. Please contact the Jayhawk team directly if you have any questions or comments.


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July 1, 2019by Jayhawk0

Readily available epoxy chemistries such as amine curing technologies dominate the market, but are they the best option when parts must retain critical physical, mechanical and electrical properties at higher temperatures for sustainable periods of time? General education and training naturally focus on widely applicable chemistries rather than niche formulations for high-performance applications. While multifunctional epoxy resins can increase performance using standard epoxy curatives, using specialty anhydride curatives is often the better option.

In the following video, our expert panel discusses specific examples of a lack of exposure to epoxy-anhydride cure systems leading to misconceptions and users overlooking the benefits of anhydride curing technology. In future videos, we will look at specific applications and emerging technologies where you can gain a competitive advantage with epoxy-anhydride cure systems.

Investigation into Epoxy Systems from Fine Chemical & Formulating Experts

To provide more information on epoxy-anhydride formulations, Jayhawk Fine Chemicals, Crosslink Technologies, Evonik, and Dixie Chemicals performed an investigation into various anhydride cure systems, with an added focus on accelerator selection. The results of this study provide key formulating tips to help ensure you select the best possible epoxy resin cure system for your specific applications.

Thought leaders from these companies sat down to discuss the results of this investigation and share their combined industry experience with specialty anhydrides and epoxy resin formulation. These videos provide valuable insight into the application of epoxy-anhydride cure systems as well as guidance on formulation and accelerator selection.

Be sure to subscribe to our YouTube channel using the link below to get notifications with each new release. Please contact the Jayhawk team directly if you have any questions or comments.


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June 28, 2019by Jayhawk0

In Video 2 of our series on epoxy-anhydride cure systems, our panel of experts discuss the advantages of using DGEBA epoxy resins with anhydride cure systems as a creative alternative to more complex and expensive multifunctional epoxies.

If you need to formulate an epoxy system that maintains its physical, mechanical, and electrical properties when exposed to high-temperature environments for sustainable periods, epoxy-anhydride cure systems provide an elegant, cost-effective solution. Formulators use epoxy-anhydride cure systems in the manufacture of adhesives, wire enamels, potting compounds, and various other components for smart phones, electric motors, protective coatings and more.

Investigating Epoxy-Anhydride Cure Systems

Utilizing epoxy-anhydride cure systems allow you to meet the highest specifications at an improved price point. Over the course of this video series, our experts discuss the practical application of epoxy-anhydride cure systems and provide data and tips to help with formulations. The data are based on a recent study into various epoxy-anhydride cure systems, with a focus on accelerator selection. This video series will provide valuable insights to formulators at any experience level.

If you missed our last video, see Formulating Tips for Epoxy-Anhydride Cure Systems: Benefits and Successes. The next video will discuss Processing Considerations when formulating epoxy-anhydride cure systems. Be sure to subscribe to our YouTube channel using the link below to get notifications with each new release. You can also contact the Jayhawk team directly if you have any general queries.


This video is part of a joint initiative by Jayhawk Fine Chemicals, Crosslink Technologies, Evonik and Dixie Chemicals to support the advancement of epoxy-anhydride cure system technology.


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June 17, 2019by Jayhawk0

Modern technology demands specialized materials that function in extreme environments. Even as performance requirements increase, there is pressure to achieve results at the best possible price point. But balancing processing/property requirements such as curing temperature, curing cycle, heat resistance and toughness is no easy task. Specialized, multifunctional epoxy resins offer one path. But what if you can achieve the results you seek at a lower cost by using traditional DGEBA epoxy resins?

With a history of use dating back to the 1960s, anhydrides are time-tested and versatile thermal curatives for epoxy resins. While they represent legacy technology, epoxy-anhydride cure systems produce modern components for products including smartphones and electric vehicles.

Investigation into Epoxy Systems from Fine Chemical & Formulating Experts

Jayhawk Fine Chemicals, Crosslink Technologies, Evonik, and Dixie Chemicals collaborated on a robust investigation of various epoxy-anhydride cure systems, with a focus on accelerator selection. The results of this study will provide you with applied data and helpful tips to help formulate epoxy cure systems.

Thought leaders from these companies sat down to discuss the results and share their combined industry experience. We are excited to release this discussion as a series of videos to provide you with valuable insights into epoxy resin cure systems and key formulating tips.

The first video provides a review of the benefits and successes of epoxy-anhydride systems. Future editions will expand on a variety of related topics and provide you with further guidance. If you have experience using epoxy-anhydride cure systems or are considering them for the first time, these short videos will offer valuable and insightful information. Be sure to subscribe to our YouTube channel using the link below to get notifications of each new release. If you have any general queries, feel free to contact the Jayhawk team directly.


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June 3, 2019by Jayhawk0

Fine chemical custom manufacturers occupy a complex global landscape characterized by various pressures: increasing make-or-buy decisions; more stringent environmental guidelines; novel methods of securing sales channels and partnerships. Each of these challenges comes silver-lined by opportunity, with significant levels of investment presenting chances for cooperation and successful business growth.

Jayhawk recently entered a strategic partnership with the leading European chemicals company CABB. This transatlantic partnership has fostered significant business growth for both entities and is expected to continue paying dividends in the coming business years as the companies draw closer together. With a secure foothold in the US and Europe, the CABB-Jayhawk partnership is uniquely poised to provide extensive fine chemical custom manufacturing services worldwide, with core competencies in fields as varied as the synthesis of active ingredients (AIs) and intermediates for agrochemicals, as well as chemical building blocks for specialties.

Now, the team would like to invite you to learn more about our unique arrangement at Chemspec Europe 2019.

Outlining Chemspec Europe 2019

In 2019, Chemspec Europe enters into its 34th edition. The exhibition has developed an outstanding international reputation as a platform for industry experts, professionals, and thought leaders to share their insights from the mutable fine chemicals market. Exhibitors from across the world will join CABB and Jayhawk to discuss business opportunities, market trends, regulatory issues, and technical innovations in specialty and fine chemicals manufacturing and supply.

The Jayhawk team will be exhibiting alongside a host of professionals, sharing our expertise in overcoming industry challenges for a variety of agrochemical and specialty customers.

Meet the Fine Chemicals Team at Chemspec Europe

Jayhawk Fine Chemicals Corporation entered the CABB network in late 2018. This will be the team’s first Chemspec Europe as part of the global enterprise of specialty and fine chemicals manufacturers that continues to defy expectations in terms of cooperative performance in the complex global fine chemicals marketplace.

If you would like to book an appointment to talk with a member of the Jayhawk team at Chemspec Europe, please do not hesitate to contact us here.