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September 3, 2020by Jayhawk0

Businesses the world over are beginning to adapt to the new reality of a marketplace defined by COVID-19. That includes fine chemical manufacturers. The first real indication that the novel coronavirus was going to significantly impact chemical supply chains came on the 30th January, when the World Health Organisation (WHO) declared a Public Health Emergency of International Concern (PHEIC). At that point, the global response to SARS-CoV-2 and the virus itself began to accelerate.

Cases rose exponentially as countries closed borders, locked down specific regions, and ordered widespread industrial shutdowns. As early as March, it was believed that as much as 94% of the Fortune 1000 were beginning to feel the economic sting of COVID-19. Though this was primarily attributed to supply chain disruptions, the impact on sales and marketing cannot be understated.

Fine Chemicals Tradeshows: A Victim of COVID-19?

Tradeshows form the backbone of the fine chemicals industry in terms of sales and marketing. Although many market segments have pivoted towards a digital-first marketing strategy in recent years, manufacturing and science still rely heavily on a physical presence in a conference setting. Unfortunately, the busy progression of professionals from all over the world within a confined space represents the perfect conditions for viral transmission. Wholesale cancellations throughout 2020 were an inevitability.

The short-term effects of this are unquantifiable, though it is easy to speculate on the severity of a business’s financial losses and the degree to which they rely on tradeshow marketing. This applies to the vast majority of fine chemicals businesses. How this will affect the landscape of the industry going forward, as more and more conferences adopt a virtual approach, remains to be seen.

Adapting to the New Normal: Fine Chemicals Marketing in 2020

You could argue that the so-called new normal – where employees predominantly work remotely, where busy events are restricted or moved to digital forums, and marketing efforts are moved almost exclusively online – is not a symptom of COVID-19 at all. The shift towards flexible working and digital-first marketing platforms has been occurring for years; the pandemic merely accelerated the rate of change.

This is not to say that the tradeshow is dead and buried, nor that digital marketing is a like-for-like replacement for your previous marketing efforts. The virtual forums have proven incredibly valuable, with conferencing software making it easier – and cheaper – than ever to connect with like-minded professionals from across the globe. We have also noticed a dramatic uptick in social media engagement, with more fine chemical manufacturers beginning to find value in the likes of LinkedIn. These go some way to emulating that tradeshow effect.

At CABB, we sincerely hope to see the return of large-scale fine chemicals events and tradeshows. However, we have also discovered a lot from lockdown that we would like to carry forward into the future. Particularly, the ability to respond to unprecedented challenges through constant innovation and shifting towards digital marketing as and when required.

If you would like to learn more about the digital marketing efforts we are making in response to the COVID-19 pandemic, simply contact a member of the CABB team today.


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August 19, 2020by Jayhawk0

Heterocycles are one of the largest classes of organic compounds worldwide. They are formed through a process known as heterocyclic synthesis, where carbon atoms and at least one heteroatom – non-carbon atom – bind into a ring. While heterocyclic chemistry is complicated, fine chemical manufacturers routinely generate large volumes of heterocycles for an array of applications.

Though heterocycles can be partially or fully saturated, aromatic are the most stable, which explains their value to a wide variety of products. Today, heterocyclic synthesis is important for agrochemicals and pharmaceuticals, with growing applications in optoelectronics markets. Heterocycles are also increasingly useful as flavoring agents and dyes, as well as intermediates in organic synthesis.

The rich variety of end-uses of heterocyclic compounds comes down to the increasing diversity of synthesis techniques. There are many ways to produce heterocyclic rings, but the most common processes involve the use of precursors to synthesize the desired molecule, modification of an existing heterocyclic or carbocyclic ring, or modifying the substituents on an existing heterocycle.

Fine Chemical Heterocyclic Synthesis in Agrochemical & Health Industry

Heterocyclic compounds containing nitrogen, oxygen, and sulfur are important components in the production and development of crop protection chemicals and active pharmaceutical ingredients (APIs). Azole type heterocyclic rings (5-member rings containing one nitrogen and at least one additional heteroatom) are a common building block for an entire class of antifungal known as azole antifungals. These chemicals are used in both fungicides and as anti-fungal medications. Fine chemical manufacturers provide key building blocks and intermediaries to support the synthesis of these important molecules.

Fine Chemical Heterocyclic Synthesis in Electronics & Other Industries

Heterocyclic building blocks are a key part of ongoing research into organic semiconductors. These semiconductors tend to be more flexible and have a low processing temperature which makes them ideal for electronics applications that may require flexibility. Custom fine chemical manufacturers, with their traditional expertise supporting the agro and pharma industries with high purity chemicals using heterocyclic synthesis, are well positioned to support the scale-up of this technology with extremely high purity profiles.

Heterocyclic Synthesis at CABB

CABB Group is a leading fine chemical custom manufacturer of starting materials, advanced intermediates, and active ingredients. CABB’s Custom Manufacturing business supports customers from 3 locations: Pratteln, Switzerland; Kokkola, Finland; and Jayhawk, USA, to offer creative solutions involving heterocyclic synthesis.

If you would like more information about our products and services, simply contact a member of the CABB team today.


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August 5, 2020by Jayhawk0

Formylation reactions occur when a formyl group (-CH=O) is added to a compound, primarily during the synthesis of aldehydes, formamides, and formate esters. They are commonly used as an intermediate step in chemical manufacturing as the formyl group can be replaced relatively easily by a different functionality. This renders formylation an extremely useful manufacturing process for an array of applications, from agrochemicals and pharmaceuticals to cosmetics and textiles.

Formylation in Fine Chemical & Custom Chemical Manufacturing

Formylation is a common reaction in fine chemical and custom fine chemical manufacturing in fields requiring high purity intermediaries. Among the most common formylation reactions are those that use Reimer-Tiemann reactions as a first step, but with so many different applications and molecules, there is a variety of possible formylation types available. As mentioned, two of the most common examples include the production of aldehydes and formamides.

Chemical manufacturers often rely on formylation as a key pathway to fine chemical formamide production, particularly in the agrochemicals industry where formamides are routinely used as intermediates in fungicides and pesticides. To a lesser – but no less valuable extent – formamides are useful for synthesizing active ingredients and intermediates in pharmaceuticals.

Manufacturers also utilize formylation to produce aldehyde molecules for a diverse set of applications. One of the most well-known aldehydes is 4-Hydroxy-3-methoxybenzaldehyde – better known as vanillin or vanilla extract. This forms the basis of countless flavoring agents and fragrances around the world. As with formamides, aldehyde molecules are also extremely useful in the agrochemicals and pharma markets.

Fine chemical companies use formylation to produce intermediates for an extremely broad cross-section of industries. For key intermediates that are not readily available, fine chemical manufacturing offers a means to secure long term supply without having to tie-up otherwise-valuable internal resources.

Formylation at CABB

CABB Group is a leading fine chemical custom manufacturer of starting materials, advanced intermediates, and active ingredients. CABB’s Custom Manufacturing business supports customers from 3 locations: Pratteln, Switzerland; Kokkola, Finland; and Jayhawk, USA, to offer creative solutions involving formylation.

If you would like more information about our products and services, simply contact a member of the CABB team today.

 


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May 19, 2020by Jayhawk0

Azo compounds are a diverse set of both natural and synthetic molecules containing at least one double-bonded nitrogen group (the “azo” group). Though there is an extremely wide range of azo compounds, the most common are pigments and dyes.

Bismarck Brown was the first commercial azo dye, which was produced from 1863. This sparked significant growth in the use of azo compounds during the 1880s, yielding a rich variety of additional azo dyes that were primarily used in the textile industry. Current applications for azo compounds include textiles, paints, printing ink, plastics, agrochemicals, pharmaceuticals, and more.

Fine Chemical Azo Compounds

Pigment and dye production generally do not require fine chemistry. However, for pharmaceutical, biomedical and agrochemical applications, fine chemical custom manufacturers play a critical role in the supply chain, addressing strict assay and impurity profiles.

Azo Compounds for Healthcare

Certain azo compounds are known to have antibiotic, antiviral, antifungal, antineoplastic, and cytotoxic properties. Fine chemical azo compounds can be a regulated starting material or an active pharmaceutical ingredient (API) for medications. Azo compounds can also be used to improve the delivery of a drug or for cellular staining to help the study of cells. Current research into naturally-occurring azo compounds is continually identifying potential new drugs to treat a wide variety of diseases.

Azo Compounds for Agrochemicals

Because of the way azo compounds react to light, there are many unique opportunities for their use in agrochemicals. For example, azobisisobutyronitrile (AIBN), an alkyl rather than an aromatic azo compound, is commercially important as a radical initiator in a wide variety of processes. Azo compounds have also been used to study how insecticides work by using azo compounds to turn the insecticide on and off with light for easier handling and more controlled experiments.

How are Fine Chemical Azo Compounds Produced?

There are several different methods of producing fine chemical azo compounds. One is through the use of azo coupling with a diazonium salt, formed by the oxidation of an aniline with nitric acid, and another aniline type molecule. Another route involves the oxidation of substituted hydrazines and the condensation of anilines with aryl nitro compounds, followed by oxidation of the azoxy intermediate. Finding the best pathway depends on a multitude of factors – a fine chemical manufacturing partner can help identify and refine the best way to obtain commercial quantities.

Azo Chemistry at CABB

CABB Group is a leading fine chemical custom manufacturer of starting materials, advanced intermediates, and active ingredients. CABB’s Custom Manufacturing business supports customers from 3 locations: Pratteln, Switzerland; Kokkola, Finland; and Jayhawk, USA, to offer creative solutions involving Azo chemistry.

If you would like more information about our products and services, simply contact a member of the CABB team today.

 

References:

https://www.ncbi.nlm.nih.gov/pubmed/29792144

https://aip.scitation.org/doi/pdf/10.1063/1.4945973

https://www.nature.com/articles/srep13962

 


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March 6, 2020by Jayhawk1

Coronavirus, more accurately referred to as COVID-19, is beginning to impact global supply chains in a tangible way. Although it is impossible to forecast the effect of numerous epidemics worldwide on the fine chemical supply chain specifically, reports suggest that as much as 94% of the Fortune 1000 are already experiencing coronavirus-related supply disruptions.

Fortune cites the devastating 2011 tsunami as a case study of how unforeseeable disasters can severely disturb supply chains with far-reaching ramifications. Damage to Mitsubishi Gas Chemical factories in the area affected by the tsunami led to a shortage of bismaleimide triazine (BT) resin; a critical material for electronic substrates. Over 90% of the world’s BT was engineered in northeastern Japan at the time. The result was a significant delay in electronic chip production and assembly of consumer digital devices.

Understanding the Fine Chemicals Supply Chain

Much like the global electronics industry, the fine chemicals market is built on a closely intertwined supply chain that could easily be disturbed by the currently intensifying climate.

Specialty and fine chemicals occupy a small but lucrative niche of the global chemical industry; a closely interlinked market that relies on the reliability of supply. Complex and pure chemical substances (fine chemicals) must be sourced, screened, and delivered in a timely fashion to facilitate the synthesis of complex compounds (specialty chemicals) that are selected for their performance rather than their compositional values. These intermediates underlie a potentially limitless range of market-oriented and functional products, from pharmaceuticals to petrochemicals.

Read More: Managing Your Pyromellitc Dianhydride Supply Chain in a Volatile Market

In recent years, the fine chemicals market has – like many others – been characterized by an East vs. West dichotomy. Asian chemical companies have been growing at rapid rates with low investment costs and typically reduced costs associated with regulatory compliance. The growth of China’s chemical market has proven particularly disruptive to the US as major players continue to acquire valuable secondary assets and invest in new intellectual properties. Chinese API manufacturers and pharmaceutical companies now service an extremely large proportion of the global market.

How Will Coronavirus Effect Fine Chemicals Supply?

Fears of coronavirus-related pharmaceutical ingredient shortages are subsequently well-placed. Large areas of China have ground to a halt due to quarantine protocols, which have caused worker shortages, market shutdowns, raw material shortages, and so on. The logistics of how to manage the bottlenecks of provincial border checkpoints has also become a factor affecting the global supply of fine chemicals and pharmaceuticals.

Even once ingredients are manufactured and successfully delivered out of the country, strict quarantine protocols at destination ports can result in a further delay of at least 14-days. Cancellations of product shipments are increasingly common as the virus propagates worldwide. From a pharmaceutical perspective, this is potentially hazardous as the reduced supply of APIs and pharma excipients to manufacturers that rely on raw materials from the large Chinese market could lead to a shortage of key medicines. Industry officials say that this is far from the case thus far but add that sustained supply chain disruptions could impact the availability of medicines down the line.

From the point of view of petrochemicals, industry analysts actually predict a decrease in demand due to closures or decreased productivity of factories using petrochemical feedstocks downstream, such as plastics processing. Consequently, industrial fine chemicals are likely to be sandwiched by COVID-19 related logistical issues including reduced supply and demand.

Current Fine Chemicals Supply Situation at CABB

CABB Group is a leading fine chemical custom manufacturer of starting materials, advanced intermediates and active ingredients.  CABB’s Custom Manufacturing business supports customers from 3 locations: Pratteln, Switzerland; Kokkola, Finland; and Jayhawk, USA to offer creative sourcing options while addressing supply chain security. We’ve minimized our raw material risk exposure and are working diligently to ensure continuous manufacturing operations and deliveries to global customers without disruption.

If you would like more information about our fine chemicals supply chain, simply contact a member of the CABB team today.

 

 

https://fortune.com/2020/02/21/fortune-1000-coronavirus-china-supply-chain-impact/

https://www.eetimes.com/update-analysts-fear-shortage-of-key-resin/#

https://www.scmp.com/economy/china-economy/article/3051534/coronavirus-chinas-manufacturing-supply-chain-pummelled-all


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August 15, 2019by Jayhawk0

Formulating Tips for Epoxy-Anhydride Cure Systems 8: Understanding BTDA Blends

Curing a basic DGEBA epoxy resin with a monoanhydride and dianhydride blend improves the thermal stability of your epoxy-based parts when operating in aggressive service environments. You are also able to adjust the blend to meet specific processing conditions while achieving a favorable cost position.
Accomplishing this requires careful consideration of specific parameters, including:

  • Selection of the anhydrides
  • Dianhydride/monoanhydride ratio
  • Accelerator selection and dosing level
  • Cure schedule

The Advantages of BTDA Blends

BTDA/NMA blends are an intriguing example of a dianhydride and monoanhydride combination that can deliver high-quality results. They also address the incorporation of a solid dianhydride into a liquid epoxy resin without resorting to solvents or diluents. If you are willing to take the time to formulate correctly, you can leverage blended epoxy-anhydride cure systems to gain a competitive advantage. In the video below, our experts discuss BTDA/NMA blends in greater detail.

Are you looking for more technical data on BTDA/NMA formulations? Do you have any other questions or comments on curing epoxy resins with anhydrides? Please reach out to us, we are happy to help.

Epoxy-Anydride Formulating Tips from the Experts

Jayhawk Fine Chemicals, Crosslink Technologies, Evonik and Dixie Chemicals performed a study on a variety of BTDA and NMA blends, with an emphasis on accelerator selection. A detailed presentation can be found here.

If you missed our last video, Formulating Tips for Epoxy-Anhydride Cure Systems 7: Pushing the Envelope, be sure to give it a watch. You can subscribe to our YouTube channel using the link below to get notifications with each new release.


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August 8, 2019by Jayhawk0

Modern technology is increasing the demand for high-performance components and creating opportunities for epoxy-anhydride systems to offer solutions in a variety of new applications. Filament-wound components, prepregs, bulk and sheet-molding compounds, and optically clear encapsulants are just some of the areas where epoxy-anhydride cure systems offer new and exciting options in demanding service environments.

Novel applications for epoxy-anhydride cure systems means new property requirements. For example, traditional epoxy-anhydride chemistry focuses on maximizing Tg and heat resistance; modern applications require a more careful balance of heat resistance and toughness. Similarly, traditional applications are tolerant of some coloration whereas new applications may require a water-white product. On the processing side, epoxy-anhydride cure systems need to maximize throughput without requiring new and expensive assets. This means finding ways to reduce curing temperatures and curing times. With the correct formulation, you can create a high-value epoxy-resin cure system that meets these challenges and provides a competitive edge.

In this video, our thought leaders provide further insight into the challenging new requirements epoxy-anhydride cure systems must meet. As the series continues, we will tackle different aspects of formulating mono/dianhydride blends with accelerators to help achieve the results you need.

Epoxy-Anhydride  Formulating Tips from the Experts

Jayhawk Fine Chemicals, Crosslink Technologies, Evonik, and Dixie Chemicals performed a study on a variety of specialty anhydride cure systems, with an emphasis on accelerator selection. The results of this study provide a foundation for improving epoxy-anhydride formulations and for creating new growth opportunities for formulators.

Thought leaders from these companies sat together to discuss the results as part of an informative video series. If you missed our last video, Formulating Tips for Epoxy-Anhydride Cure Systems 6: Processing Considerations, be sure to check it out. If you have any questions or comments, please contact a member of the team.

Be sure to subscribe to our YouTube channel using the link below to get notifications with each new release. If you have any questions or comments, please contact us directly.


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August 5, 2019by Jayhawk0

Epoxy-anhydride cure systems impart outstanding physical, mechanical, and electrical properties for a variety of critical applications. Fabricated parts are resistant to high-peak and continuous-use temperatures, retaining their properties in extreme operating conditions. With some basic processing and formulation considerations, you can utilize DGEBA class resins and create a high-performance epoxy at a competitive price point.

In the video below, our expert panel discuss processing considerations for epoxy-anhydride resin systems. We explore ways to overcome some of the perceived challenges in epoxy processing such as how to incorporate solid dianhydrides into a liquid resin. We also cover the use of monoanhydrides as reactive diluents and co-curatives along with other key topics. With proper formulation, blended curatives deliver the physical properties you seek in an elegant, easy-to-use, and cost-effective manner.

As the series continues, the panel will address specific process and formulation considerations to fully leverage epoxy-anhydride cure systems. Topics will include how to determine the correct levels of dianhydride and monoanhydride loading; and how to choose the correct accelerator for epoxy-anhydride cure system systems; and other formulation concerns to help give you a competitive edge.

A Comparative Analysis of Epoxy-Anhydride Cure Systems

Specialty anhydride and formulating experts from Jayhawk Fine Chemicals, Crosslink Technologies, Evonik, and Dixie Chemicals performed a study on a variety of specialty anhydride cure systems, with an emphasis on accelerator selection. The results provide valuable data and guidelines to help with your formulations and form the basis of our video series.

Please subscribe to our YouTube channel using the link below to receive notifications with each new release. If you missed it, make sure you check out our previous post Formulating Tips for Epoxy-Anhydride Cure Systems 5: Modern ApplicationsBe sure to subscribe to our YouTube channel using the link below to get notifications with each new release. If you have any questions or comments, please contact us directly.


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July 11, 2019by Jayhawk0

The market for high-temperature, high-endurance epoxy polymers continues to grow. This growth is largely driven by demand for consumer and automotive electronics to be more durable, lighter, increasingly compact, and able to function in various environments. As expectations increase, specifications normally found in niche products are becoming widespread in commercial versions. Epoxy-anhydride cure systems have a long tradition of meeting stringent specifications and continue to provide the best, most efficient path for epoxy formulators.

In the video below, our expert panel discusses the exciting growth in demand for epoxy-anhydride cure systems. In the next video, they will discuss how brand-new applications for anhydride cured epoxy resin provide even more opportunities for growth.

Investigation on Epoxy-Anhydride Cure Systems from specialty anhydride and formulating experts

To help you take advantage of the growing demand for epoxy-anhydride systems, Jayhawk Fine Chemicals, Crosslink Technologies, Evonik, and Dixie Chemicals completed an investigation into a variety of anhydride curatives, with a focus on accelerator selection. These results offer valuable data and guidelines for new users or experienced formulators looking to improve on epoxy resin performance.

Experts from these companies discuss the key benefits and applications of epoxy-anhydride cure systems. Previous videos review historic applications and the value proposition of epoxy-anhydride cure systems, as well as the need to dispel misconceptions. The next video will discuss how future technologies are providing even more opportunities to expand the market. After that, our panel will begin to discuss processing considerations and specific formulations to achieve the results you need.

Be sure to subscribe to our YouTube channel using the link below to get notifications with each new release. Please contact the Jayhawk team directly if you have any questions or comments.


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July 1, 2019by Jayhawk0

Readily available epoxy chemistries such as amine curing technologies dominate the market, but are they the best option when parts must retain critical physical, mechanical and electrical properties at higher temperatures for sustainable periods of time? General education and training naturally focus on widely applicable chemistries rather than niche formulations for high-performance applications. While multifunctional epoxy resins can increase performance using standard epoxy curatives, using specialty anhydride curatives is often the better option.

In the following video, our expert panel discusses specific examples of a lack of exposure to epoxy-anhydride cure systems leading to misconceptions and users overlooking the benefits of anhydride curing technology. In future videos, we will look at specific applications and emerging technologies where you can gain a competitive advantage with epoxy-anhydride cure systems.

Investigation into Epoxy Systems from Fine Chemical & Formulating Experts

To provide more information on epoxy-anhydride formulations, Jayhawk Fine Chemicals, Crosslink Technologies, Evonik, and Dixie Chemicals performed an investigation into various anhydride cure systems, with an added focus on accelerator selection. The results of this study provide key formulating tips to help ensure you select the best possible epoxy resin cure system for your specific applications.

Thought leaders from these companies sat down to discuss the results of this investigation and share their combined industry experience with specialty anhydrides and epoxy resin formulation. These videos provide valuable insight into the application of epoxy-anhydride cure systems as well as guidance on formulation and accelerator selection.

Be sure to subscribe to our YouTube channel using the link below to get notifications with each new release. Please contact the Jayhawk team directly if you have any questions or comments.